(Download) "Individualising Target-Controlled Anaesthesia. Better Models or Better Targets? (Editorials) (Editorial)" by R. R. Kennedy " Book PDF Kindle ePub Free
eBook details
- Title: Individualising Target-Controlled Anaesthesia. Better Models or Better Targets? (Editorials) (Editorial)
- Author : R. R. Kennedy
- Release Date : January 01, 2010
- Genre: Health & Fitness,Books,Health, Mind & Body,
- Pages : * pages
- Size : 72 KB
Description
Target-controlled infusion (TCI) has been available as a routine clinical tool for anaesthetists in Australia and New Zealand and many other parts of the world outside the USA (1) since the introduction of the Diprifusor nearly 15 years ago. More recently, the introduction of infusion devices supporting 'open TCI' has allowed TCI to be used for drugs other than propofol and given users a choice of propofol models. This apparent flexibility has produced what Enlund (2) calls "Totally Confused Infusion"--at least in our department! The commonly used propofol models have significant differences (3); there are different versions of the so-called Marsh model, the user needs to choose between plasma and effect site targeting and implementation of the same model, and therefore dosing can differ between brands of open TCI pumps. That there are multiple propofol models reflects the ongoing evolution of modelling tools and of the models themselves and the development of measures of endpoints for calibrating model performance. The ongoing quest for new and improved models also tries to overcome the known deficiencies of existing models, answer questions raised in previous studies and enhance understanding of the disposition of these agents. The paper in this issue of the Journal by Crankshaw et al (4) is part of ongoing efforts to overcome problems with previous models and enhance our understanding. This group had an interest in TCI long before the tools became available to the rest of us (5,6).
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